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EFFECTS OF ENERGY AND PROTEIN RESTRICTION ON ACETYLCHOLINE SENSITIVITY OF RAT ISOLATED PERFUSED HEART
Author(s) -
Venkataraman B. V.,
Shetty P. S.,
Joseph Thangam,
Arifullah H. Mohamed,
Stephen P. M.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00910.x
Subject(s) - chronotropic , acetylcholine , medicine , endocrinology , heart rate , chemistry , blood pressure
SUMMARY 1. Responses to acetylcholine of isolated perfused hearts obtained from rats which were acutely starved, chronically half‐starved or protein‐restricted were compared with those of paired control groups. 2. Isolated hearts of totally starved rats showed no significant change in the responses elicited by 10 and 20 μg doses of acetylcholine as compared with paired controls. With 40 μg acetylcholine a significantly greater reduction ( P < 0.001) in heart rate and coronary flow was seen and the duration of the negative chronotropic action was significantly increased ( P < 0.05), as compared with controls. 3. Isolated hearts of half‐starved and protein‐restricted rats responded to 10, 20 and 40 μg doses of acetylcholine with significantly greater reduction ( P < 0.001) in heart rate, coronary flow and increase in duration of negative chronotropic action ( P < 0.001) as compared to controls.