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EFFECTS OF D ‐PENICILLAMINE ON COLLAGEN BIOSYNTHESIS BY FIBROBLAST CELL CULTURES
Author(s) -
Chamson Annette,
Frey Jacques
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00907.x
Subject(s) - penicillamine , fibroblast , biosynthesis , chemistry , cell culture , cell , biochemistry , microbiology and biotechnology , biology , in vitro , enzyme , genetics , organic chemistry
SUMMARY 1. The effects of d ‐penicillamine on collagen and total protein synthesis by fibroblast cell cultures were studied. 2. High concentration of d ‐penicillamine (10 mmol/1) produced a toxic effect consisting of inhibition of growth and a non‐specific increase in protein synthesis. 3. A low concentration of d ‐penicillamine (100 μmol/1) decreased the biosynthesis of both type I and type III collagens.