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ACTIONS OF THE SLOW CHANNEL ACTIVATOR, BAY‐K‐8644, ON THE ELECTRICAL ACTIVITY OF 3‐DAY‐OLD EMBRYONIC CHICK HEARTS
Author(s) -
Sada H.,
Sada S.,
Sperelakis N.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00903.x
Subject(s) - tetrodotoxin , activator (genetics) , bay , biophysics , electrophysiology , medicine , embryonic heart , chemistry , endocrinology , biology , anatomy , embryonic stem cell , receptor , biochemistry , geology , oceanography , gene
SUMMARY 1. In order to assess the effects of Bay‐K‐8644 on electrical activities of young embryonic chick hearts in which the rising phase of the action potential (AP) depends on tetrodotoxin‐insensitive slow Na + currents, slow AP were recorded in spontaneously beating 3‐day‐old embryonic chick hearts. 2. Bay‐K‐8644(10 ‐6 mol/l) caused increases in the maximum rate of rise, amplitude, and duration of the slow AP; there was a slow increase in the spontaneous firing rate. 3. Thus, Bay‐K‐8644 stimulates Na + influx through TTX‐insensitive slow channels.