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FURTHER INVESTIGATIONS ON THE α 1 ‐ADRENOCEPTOR BLOCKING PROPERTIES OF AR‐C 239 IN RATS
Author(s) -
Huchet AnneMarie,
Andréjak Michel,
Lucet Bernadette,
Gautret Bruno,
Doursout MarieFrançoise,
Ostermann† Gérard,
Schmitt Henri
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00901.x
Subject(s) - clonidine , vas deferens , blocking (statistics) , adrenergic receptor , medicine , endocrinology , stimulation , chemistry , peripheral , pharmacology , receptor , statistics , mathematics
SUMMARY 1. AR‐C 239, a new α‐adrenoceptor blocking drug, appears to act selectively on α 1 sites in rats. At peripheral sites, this drug did not change the tachycardia induced by spinal sympathetic outflow stimulation in pithed rats, and did not antagonize the inhibitory effects of clonidine on this preparation. In addition, AR‐C 239 showed predominant α 1 ‐adrenoceptor blocking properties in the bisected rat vas deferens preparation. AR‐C 239 did not prevent or reverse the centrally mediated hypotensive and bradycardic actions induced by clonidine, in intact animals. 2. In conclusion, AR‐C 239 seems to be a very useful tool for the characterization of peripheral and central α 1 ‐adrenoceptors, in this animal species.