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PLASMA NORADRENALINE AND ITS RELATIONSHIP TO PLASMA OESTRADIOL IN NORMAL WOMEN DURING THE MENSTRUAL CYCLE
Author(s) -
Davidson Lisa,
Rouse Ian L.,
Vandongen Robert,
Beilin Lawrence J.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00899.x
Subject(s) - menstrual cycle , endocrinology , medicine , plasma concentration , plasma , chemistry , hormone , physics , quantum mechanics
SUMMARY 1. In order to investigate a possible relationship beween sympatho‐adrenal neuronal activity and the endocrine changes during the menstrual cycle, free and sulphate‐conjugated plasma catecholamines and oestradiol were measured under carefully controlled conditions in 26 normal menstruating women. 2. Plasma oestradiol levels were generally higher during the luteal compared with the follicular phase which corresponded to the self‐reported day of the cycle. 3. Free plasma noradrenaline concentration was higher during the luteal phase ( P = 0.02) and was positively correlated with plasma oestradiol concentration ( r = 0.40, P = 0.023). These relationships were not present for plasma adrenaline. 4. It is conceivable that the higher luteal phase noradrenaline is causally related to the higher oestradiol levels, leading to incomplete inactivation by reducing tissue uptake or competitive inhibition of catechol‐ O ‐methyl transferase. 5. As sulphated noradrenaline was not significantly different between the follicular and luteal phases, competitive inhibition of phenolsulphotransferase by oestradiol was considered unlikely.