Premium
EFFECT OF PROSTAGLANDIN E 2 ON SERUM IRON AFTER ACUTE AND CHRONIC BLOOD LOSS
Author(s) -
AlWaili Noori S.,
ALAzzawi Hani T.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00892.x
Subject(s) - subcutaneous injection , prostaglandin , prostaglandin e2 , medicine , blood loss , weight loss , endocrinology , body weight , prostaglandin e , chemistry , surgery , obesity
SUMMARY 1. The effect of prostaglandin E 2 on serum iron of New Zealand rabbits subjected to acute and chronic blood loss is demonstrated. 2. The results showed that acute blood loss was followed by significant elevation of serum iron when sera were tested on day three after the bleeding. With subcutaneous injection of 40μg/kg body weight of prostaglandin E 2 for each 12 h of the experiment, acute blood loss was followed by a significant reduction in serum iron within the same period. 3. Similar results were obtained after chronic blood loss when subcutaneous injection of 20 μg/kg body weight of prostaglandin E 2 was used for each 12 h of the experiment. 4. It could be concluded that the prostaglandin E 2 causes marked lowering of serum iron following blood loss.