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CORRELATION OF PLASMA ANGIOTENSIN II CONCENTRATION AND PLASMA RENIN ACTIVITY DURING ACUTE HYPOXIA IN DOGS
Author(s) -
Raff Hershel,
Maselli Judy,
Reid Ian A.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00307.x
Subject(s) - plasma renin activity , renin–angiotensin system , radioimmunoassay , medicine , endocrinology , hypoxia (environmental) , chemistry , in vivo , angiotensin ii , plasma concentration , oxygen , biology , blood pressure , microbiology and biotechnology , organic chemistry
SUMMARY 1. The effects of isocapnic hypoxia on plasma renin activity (PRA) and angiotensin II (AH) concentration were studied in anaesthetized, artificially ventilated dogs. Regression analysis of plasma All concentration vs PRA, both measured by radio‐immunoassay (RIA), was used as an index of converting enzyme activity in vivo. 2. P a O 2 decreased from 82 to 30 mmHg but regression analysis did not reveal any inhibition of All production within the limits of detection of this method (<20% inhibition). 3. We conclude that systemic converting enzyme activity, assessed by in vivo measurement and correlation of PRA and AII, is not inhibited by severe hypoxia.