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PARADOXICAL CARDIOVASCULAR RESPONSE TO VISCERAL AFFERENT STIMULATION IN THE ESTABLISHED SPONTANEOUSLY HYPERTENSIVE RAT
Author(s) -
Koyama Shozo,
Manning John W.
Publication year - 1985
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1985.tb00300.x
Subject(s) - splanchnic , stimulation , splanchnic nerves , afferent , endocrinology , medicine , pressor response , spontaneously hypertensive rat , nerve stimulation , blood pressure , hemodynamics , heart rate
SUMMARY 1. Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. 2. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. 3. It is suggested that the central integrated mechanisms for activating a cardiovascular state change as evoked by visceral afferents may differ in the established hypertensive rat from that of the normotensive.