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EFFECT OF DIETARY UREA ON BLOOD PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Wang Hong,
Ikeda Katsumi,
Kihara Masahiro,
Nara Yasuo,
Horie Ryoichi,
Yamori Yukio
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00867.x
Subject(s) - urea , medicine , endocrinology , diuretic , blood pressure , chemistry , metabolite , excretion , urine , sodium , essential hypertension , biochemistry , organic chemistry
SUMMARY 1. The feeding of a normal diet containing 13.5% urea (in place of protein in a high protein diet) attenuated the development of severe hypertension and decreased the incidence of stroke in spontaneously hypertensive rats (SHR), when 1% NaCl solution was given to them. 2. The urea not only increased urine volume, but also increased urinary sodium excretion in SHR given 1% NaCl for drinking. 3. Although there was no obvious difference in erythrocyte size between the urea and the control groups, there was a significant inverse correlation between plasma urea level and erythrocyte size. 4. These results suggest that a high protein diet reduced blood pressure partly through the diuretic effect of urea, the common metabolite of various proteins.