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A DOUBLE‐BLIND CONTROLLED CLINICAL TRIAL OF MASTIC AND PLACEBO IN THE TREATMENT OF DUODENAL ULCER
Author(s) -
AlHabbal Mohammad Jamil,
AlHabbal Zakaria,
Huwez Farhad Umer
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00864.x
Subject(s) - medicine , placebo , double blind , clinical trial , duodenal ulcer , peptic ulcer , surgery , gastroenterology , alternative medicine , pathology
SUMMARY 1. A double‐blind clinical trial was carried out on thirty‐eight patients with symptomatic and endoscopically proven duodenal ulcer to compare the therapeutic responses to mastic (1 g daily, twenty patients) and placebo (lactose, 1 g daily, eighteen patients) given orally over a period of 2 weeks. 2. Symptomatic relief was obtained in sixteen (80%) patients on mastic and in nine (50%) patients on placebo, while endoscopically proven healing occurred in fourteen (70%) patients on mastic and four (22%) patients on placebo. The differences between treatments were highly significant ( P <0.01). Mastic was well tolerated and did not produce side effects. 3. It is concluded that mastic has an ulcer healing effect, but further studies are needed to establish its role in treating peptic ulcer.