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THE RENIN‐ANGIOTENSIN SYSTEM AND HYPERTENSIVE LEFT VENTRICULAR HYPERTROPHY IN THE RAT
Author(s) -
Newling R.,
Fletcher P. J.,
Duggin G. G.
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00291.x
Subject(s) - medicine , renin–angiotensin system , kidney , ventricle , plasma renin activity , muscle hypertrophy , left ventricular hypertrophy , blood pressure , endocrinology , cardiology
SUMMARY 1. The relationship between left ventricle‐to‐body weight ratio (LV/BW), mean arterial pressure (MAP, the average of 12 h of intra‐arterial monitoring in conscious animals) and plasma renin activity (PRA) was assessed at 12 weeks after unilateral clipping or sham operation in twenty‐four one‐kidney rats and twenty‐six two‐kidney rats. 2. The degree of hypertension and left ventricular hypertrophy were similar in one‐kidney and two‐kidney groups. There was a close linear relationship between LV/BW and MAP which was similar in one‐kidney and two‐kidney rats. 3. PRA was significantly elevated only in two‐kidney rats and was not related to the degree of hypertrophy after accounting for the effect of PRA on MAP. 4. These data suggest that activation of the renin‐angiotensin system does not contribute directly to myocardial hypertrophy in rats with renal‐clip hypertension.