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PHARMACOLOGICAL ACTIVITIES OF THE ANTIHYPERTENSIVE DRUG URAPIDIL IN THE RAT
Author(s) -
Verberne A. J. M.,
Rand M. J.
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00289.x
Subject(s) - urapidil , bradycardia , clonidine , antihypertensive drug , vagotomy , pharmacology , chemistry , antagonist , blockade , medicine , endocrinology , anesthesia , heart rate , blood pressure , receptor
SUMMARY 1. Urapidil had blocking activity on α 1 ‐adrenoceptors in the rat isolated caudal artery (pA 2 ≏ 7) and in the anaesthetized rat. 2. Urapidil had no clonidine like agonistic activity on α 2 ‐adrenoceptors in preparations of the guinea‐pig ileum (prejunctional) or dog saphenous vein (postjunctional). 3. Urapidil (0.01–0.1 mg/kg i.v.) had a hypotensive effect in the anaesthetized rat. In a dose of 0.1 mg/kg, the depressor response was accompanied by bradycardia. Vagotomy abolished the bradycardia and attenuated the depressor response. 4. The results indicate that the antihypertensive effect of urapidil may be due partly to blockade of postjunctional α 1 ‐adrenoceptors, but in addition there is a central component of action.