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INTRACEREBROVENTRICULAR INFUSIONS OF CORTICOTROPHIN RELEASING FACTOR (CRF) AND ACTH RAISE BLOOD PRESSURE IN SHEEP
Author(s) -
Scoggins Bruce A.,
Coghlan John P.,
Denton Derek A.,
Fei David W.,
Nelson Mark A.,
Tregear Geoffrey W.,
Tresham Janette,
Wang XiaoMing
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00280.x
Subject(s) - blood pressure , medicine , endocrinology , cerebral ventricle , ventricle , mean arterial pressure , stimulation , heart rate , anesthesia
SUMMARY 1. Infusion of synthetic ovine CRF (10 or 100 μg/h) into the lateral cerebral ventricle for 24 h increased mean arterial blood pressure of conscious sheep. 2. CRF infusion also increased urine output and sodium excretion. 3. Intravenous infusion of CRF (100 μg/h) or intraventricular infusion of artificial CSF had no effect on blood pressure. 4. Intraventricular infusion of ACTH (1–24) at 0.5 μg/kg per day, a rate of infusion which has no systemic effect on blood pressure, also raised mean arterial pressure. 5. These studies suggest that two peptides involved in the physiological response to ‘stress’ may influence blood pressure by mechanisms which do not involve stimulation of adrenocortical steroid production.