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EFFECT OF ANTIHYPERTENSIVE DRUGS ON NEONATAL BLOOD PRESSURE
Author(s) -
HendersonSmart D. J.,
Horvath J. S.,
Phippard A.,
Korda A.,
Child A.,
Duggin G. G.,
Hall B. M.,
Storey B.,
Tiller D. J.
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00277.x
Subject(s) - medicine , blood pressure , methyldopa , pregnancy , incidence (geometry) , birth weight , clonidine , obstetrics , gestation , apgar score , fetus , anesthesia , perinatal mortality , genetics , physics , optics , biology
SUMMARY 1. This study evaluates the perinatal outcome of infants born to ninety‐five mothers with hypertension in pregnancy whose blood pressure was treated in a double blind trial comparing clonidine hydrochloride (C) and α‐methyldopa (A). 2. There were no fetal deaths and two neonatal deaths, giving a perinatal mortality of 2%. There was no significant difference between Groups C and A with regard to the gestation or weight at birth, incidence of intrauterine growth retardation, or condition at birth as judged by Apgar scores and acid‐base status. No infant in either group developed significant hypotension or rebound hypertension. The blood pressure was not significantly different between Groups C and A, and controls. In each of these three groups there was a similar significant rise in systolic blood pressure with age.