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SUPINE HYPERTENSION, BLOOD PRESSURE VARIABILITY AND CIRCADIAN RHYTHM IN AUTONOMIC FAILURE: THE ROLE OF AMBULATORY INTRA‐ARTERIAL MONITORING
Author(s) -
Mann Stewart,
Bellamy G. R.,
Hunyor S. N.,
Raftery E. B.,
Ingall T.,
Bannister R.
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00276.x
Subject(s) - circadian rhythm , supine position , pure autonomic failure , ambulatory blood pressure , blood pressure , medicine , ambulatory , cardiology , anesthesia , orthostatic vital signs
SUMMARY 1. Blood pressure variation over 24 h was studied in twelve subjects with suspected or established autonomic failure using ambulatory intra‐arterial monitoring. 2. Three subjects who had been previously diagnosed as having orthostatic hypotension due to autonomic failure were found to have normal circulatory reflexes. 3. A generally consistent circadian variation of blood pressure was seen in the other nine subjects, pressure rising gradually from its lowest point early in the morning to a peak during the early part of the night; this pattern was also found during bed rest in four subjects. 4. Supine hypertension (an hourly mean blood presure of > 170/90 mmHg) not suspected from sphygmomanometric readings was observed in four subjects, generally during the night. 5. Heart rate variability was reduced in six subjects while short‐term blood pressure variability was markedly increased.