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EFFECTS OF Δ 1 AND Δ 6 ‐TETRAHYDROCANNABINOL ON THE ADENYLATE CYCLASE ACTIVITY IN VENTRICULAR TISSUE OF THE RAT HEART
Author(s) -
Li D. M. F.,
Ng Camay K. M.
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00242.x
Subject(s) - adenylate kinase , cyclase , endocrinology , medicine , chemistry , enzyme , enzyme assay , tetrahydrocannabinol , biology , biochemistry , receptor , cannabinoid
SUMMARY 1. Adrenaline 1 μg markedly elevated the activity of adenylate cyclase in ventricular tissue of rat hearts. 2. Δ 1 ‐THC 25, 50 and 100 μg significantly reduced the adenylate cyclase activity with the maximum effect observed with the dose or 25 μg. Doses below or above this range did not produce any significant effect on the enzyme activity. 3. Neither Δ 6 ‐THC 25 and 100 μg nor PVP 400 μg had any significant action on adenylate cyclase. 4. The Δ 1 ‐THC‐induced lowering of the cyclic AMP concentration in ventricular tissue of rat hearts can be explained, at least partly, by its ability to reduce the activity of adenylate cyclase in these tissues. It is suggested that this enzyme inhibition underlies the cardiac depressant action of Δ 1 ‐THC.