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SECRETORY AND VASCULAR EFFECTS OF THE OPTICAL ISOMERS OF NICARDIPINE
Author(s) -
Iwatsuki K.,
Iijima F.,
Chiba S.
Publication year - 1984
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1984.tb00233.x
Subject(s) - nicardipine , perfusion , chemistry , bicarbonate , secretion , blood flow , endocrinology , pharmacology , medicine , calcium , biochemistry , biology , organic chemistry
SUMMARY 1. The effects of optical isomers of nicardipine on the secretion of pancreatic juice and blood flow were investigated in the dog‐isolated, blood‐perfused pancreas. 2. Intra‐arterial administration of (‐)‐nicardipine (10–300 μg) caused a dosedependent increase in pancreatic secretion. However, the (+)‐isomer was much less potent than the (‐)‐isomer and even in 300 μg of (+)‐isomer caused only a slight secretion. 3. (+)‐ And (‐)‐nicardipine increased perfusion blood flow in a dose‐dependent manner, and (+)‐nicardipine was approximately five times as potent as the (‐)‐isomers. The maximum increase in a flow rate was produced by 30 μg of (+)‐isomer and 100 μg of (‐)‐isomer. 4. Bicarbonate concentration in pancreatic juice induced by (‐)‐ and (+)‐nicardipine was increased in a dose‐dependent manner, but the protein concentration was only increased slightly. 5. From these results, it is concluded that there is a stereoselectivity in the secretory and vascular actions of optical isomers of nicardipine.