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CARDIOVASCULAR RESPONSES ELICITED BY MICROINJECTION OF CHOLINERGIC AGENTS INTO NUCLEUS DORSALIS RAPHE IN CATS
Author(s) -
Saxena A. K.,
Pant K. K.,
Saksena A. K.,
Tangri K. K.,
Vrat S.,
Bhargava K. P.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00849.x
Subject(s) - microinjection , carbachol , muscarinic acetylcholine receptor , raphe , atropine , endocrinology , cholinergic , medicine , chlorisondamine , chemistry , microinjections , neuroscience , receptor , biology , serotonin , blood pressure , serotonergic
SUMMARY 1. The effect of cholinomimetics and cholinoceptor blocking agents microinjected into nucleus dorsalis raphe (NDR) has been studied on heart rate and blood pressure to identify the nature and role of these cholinoceptors in cardiovascular regulation. 2. Microinjection of the cholinoceptor agonists, pilocarpine and carbachol into NDR elicited bradycardia and hypotension accompanied by salivation which could be blocked by local pretreatment with ethybenztropine (a muscarinic réceptor blocker), but not by chlorisondamine (a nicotinic receptor blocker). 3. Pretreatment with atropine methylnitrate (i.v.), which blocks only peripheral muscarinic receptors, did not prevent these cardiovascular responses evoked by carbachol microinjection. 4. These cholinergic receptors seem to be localized in NDR since, microinjection of carbachol into neural structures adjoining NDR, failed to induce any cardiovascular responses. 5. Muscarinic cholinoceptors are present in NDR which modulate cardiovascular activity by influencing sympathetic preganglionic neurons in the intermediolateral columns of the spinal cord.