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CEREBRAL MECHANISMS INFLUENCING RENAL SODIUM EXCRETION IN DEHYDRATED SHEEP
Author(s) -
McKinley M. J.,
Denton D. A.,
Fryday H. W.,
Weisinger R. S.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00220.x
Subject(s) - sodium , excretion , renal physiology , chemistry , endocrinology , natriuresis , medicine , zoology , kidney , biology , organic chemistry
SUMMARY 1. Reducing the cerebrospinal fluid concentration of NaCl by infusion into a lateral cerebral ventricle of isotonic solutions of 0.3 mol/1 mannitol or sucrose at 1 ml/h for 2 h caused a large reduction in renal Na excretion in conscious sheep deprived of water for 24 or 48 h. 2. Infusion of 0.3 mol/1 mannitol into the lateral ventricle of water‐replete sheep did not alter renal Na excretion but induced a water diuresis. 3. These data indicate that during dehydration, renal Na excretion may be under the control of the brain. The pathway(s) from brain to kidney mediating this antinatriuretic effect are not known.