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EFFECTS OF IMIPRAMINE ON THE ORTHOSTATIC CHANGES IN BLOOD PRESSURE, HEART RATE AND PLASMA CATECHOLAMINES
Author(s) -
Nielsen Jens Rokkedal,
Johansen Torben,
Arentoft Anne,
Gram Lars F.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00217.x
Subject(s) - imipramine , orthostatic vital signs , supine position , blood pressure , heart rate , medicine , anesthesia , ingestion , endocrinology , alternative medicine , pathology
SUMMARY 2. Imipramine caused a moderate increase in supine systolic blood pressure, and a pronounced increase in the rise in heart rate, when the subjects assumed erect position. 3. The orthostatic drop in systolic blood pressure was in most cases only moderately increased after ingestion of imipramine, but in three subjects pronounced orthostatic hypotension developed when the sodium balance was low, whereas no clinical symptoms were seen in the same subjects when tested after imipramine ingestion on a high sodium balance. 4. The plasma catecholamine levels in supine and standing position were not influenced by imipramine or by the changes in sodium balance. 5. The data may suggest that inhibition of presynaptic reuptake of noradrenaline and/or α‐adrenoceptor blockade causes the moderate rise in supine blood pressure, whereas α,‐adrenoceptor blockade, mainly affecting the venous part of the vascular bed, may explain the orthostatic reactions.