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THE INFLUENCE OF A HIGH K INTAKE ON THE HYPERTENSIVE EFFECT OF ACTH AND DOC IN SHEEP
Author(s) -
Mills E. H.,
Coghlan J. P.,
Denton D. A.,
Scoggins B. A.,
Spence C. D.,
Whitworth J. A.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00214.x
Subject(s) - endocrinology , medicine , adrenocorticotropic hormone , hormone
SUMMARY 1. The effect of 5 days administration of ACTH or DOC, was examined before and after chronic potassium (K) loading in sheep. 2. K loading raised plasma [K], urine volume and K excretion but had no effect on mean arterial pressure (MAP). 3. On a normal K intake DOC (5 mg/day i.v.) increased MAP and plasma sodium [Na]. Plasma [K], urinary Na (day 1) and K (day 1) excretion were decreased. On a high K intake (≃800 mmol K/day), DOC lowered plasma [K] but had no effect on MAP or Na excretion. 4. The hypertensive effects of ACTH were not affected by K intake.