Premium
EFFECT OF SODIUM INTAKE ON INTRAERYTHROCYTE SODIUM CONCENTRATION IN NORMOTENSIVE SUBJECTS AND PATIENTS WITH UNTREATED MILD HYPERTENSION
Author(s) -
Myers J. B.,
Morgan T. O.,
Edwards K.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00213.x
Subject(s) - sodium , blood pressure , medicine , endocrinology , dietary sodium , essential hypertension , high sodium , low sodium diet , low sodium , chemistry , renin–angiotensin system , organic chemistry
SUMMARY 1. The effect of changing sodium intake for 2 weeks was studied. Twelve nor‐motensive subjects and five patients with mild essential hypertension were given two different levels of sodium intake for 2 weeks. 2. Overall there was no significant rise in blood pressure but all patients with hypertension had a rise in blood pressure as they went from a low to a high sodium intake. 3. Plasma sodium was not altered but red cell sodium concentration was higher on the high sodium intake. This effect was observed in both normotensive and hypertensive people. 4. Alterations observed in cell sodium concentration provide support for the hypothesis that increased dietary intake of sodium may induce hypertension by causing changes in cellular transport systems.