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DIFFERENTIAL BLOOD PRESSURE AND METABOLIC EFFECTS OF 9α‐FLUOROCORTISOL IN MAN
Author(s) -
Whitworth Judith A.,
Saines Dianne,
Thatcher Robin
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00211.x
Subject(s) - blood pressure , plasma renin activity , endocrinology , medicine , aldosterone , excretion , mineralocorticoid , hormone , body weight , urinary system , chemistry , renin–angiotensin system
SUMMARY 1. The blood pressure and metabolic effects of 9α‐fluorocortisol at 0.15 mg/day and 1.5 mg/day were examined in man. 2. At high dose, systolic pressure and body weight rose, and plasma [K + ], urinary sodium excretion and renin concentration fell. At low dose similar metabolic effects were seen but blood pressure was unchanged. 3. 9α‐Fluorocortisol has ‘mineralocorticoid’ effects in man at a dose which does not alter blood pressure. These studies do not provide evidence of a ‘hyperten‐sinogenic’ class of steroid hormone action in man.