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PERIPHERAL ADRENOCEPTORS AFTER SINO‐AORTIC DENERVATION
Author(s) -
Morris Margaret J.,
Woodcock Elizabeth A.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00209.x
Subject(s) - denervation , prazosin , yohimbine , iodocyanopindolol , medicine , endocrinology , peripheral , alpha (finance) , adrenergic receptor , beta (programming language) , receptor , surgery , antagonist , agonist , intrinsic activity , construct validity , computer science , programming language , patient satisfaction
SUMMARY 1. The effect of bilateral sino‐aortic denervation on cardiac and renal cortical α‐and β‐adrenoceptor concentrations was studied in rats by radioligand binding experiments using [ 3 H]‐prazosin (α,), [ 3 H]‐yohimbine (α 2 ) and [ 125 I]‐iodocyanopindolol (β). 2. Cardiac α‐ and β‐adrenoceptor concentrations were not altered by sino‐aortic denervation. 3. There was a significant increase in β‐adrenoceptor concentration in the renal cortex of sino‐aortic denervated rats compared to sham‐operated controls.