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ELEVATION OF BLOOD PRESSURE IN HYPERTENSIVE RATS AFTER LESIONING SEROTONIN NERVES IN THE DORSOMEDIAL MEDULLA OBLONGATA
Author(s) -
Howe P. R. C.,
Rogers P. F.,
King R. A.,
Smith R. M.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00196.x
Subject(s) - medulla oblongata , blood pressure , medulla , serotonin , medicine , solitary tract , heart rate , endocrinology , free nerve ending , 5 ht receptor , central nervous system , receptor
SUMMARY 1. The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke‐prone hypertensive rats and in normotensive rats. 2. 5HT nerves were destroyed by injecting 5,7‐dihydroxytryptamine bilaterally into the solitary tract nucleus. Immunohistochemical and biochemical examination revealed a selective loss of 5HT nerves throughout the dorsomedial medulla with little damage in adjacent regions. 3. Arterial blood pressure and heart rate, measured at daily intervals, were similar in lesioned and sham‐operated normotensive rats. However, in the hypertensive rats, blood pressure was substantially elevated at 6‐9 days after the lesions compared with sham operations. There were no accompanying changes in heart rate.