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REVERSAL OF RENOVASCULAR HYPERTENSION
Author(s) -
Swales J. D.,
Bing R. F.,
Russell G. I.,
Thurston H.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00191.x
Subject(s) - renovascular hypertension , medicine , cardiology , blood pressure
SUMMARY 1. The fall in blood pressure observed in both early and chronic phase Goldblatt 2‐kidney 1‐clip hypertension produced by removing or unclipping the ischaemic kidney is due to a profound fall in peripheral resistance. 2. The two procedures have an equal effect upon peripheral resistance and the lesser efficacy of nephrectomy in lowering blood pressure is due to a greater rise in stroke volume perhaps associated with a greater degree of sodium retention. 3. Neither changes in sodium balance, in the renin‐angiotensin system nor in vascular reactivity explain the fall in blood pressure. 4. A reduction in renal sympathetic afferent activity and a medullary based vasoactive humoral system may play a role although the nature and extent of that role remain to be defined.