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GRADED EFFECTS OF SARALASIN ON PROSTAGLANDIN E, PLASMA RENIN ACTIVITY AND RENAL BLOOD FLOW IN ANAESTHETIZED DOGS
Author(s) -
Wong Pancras C.,
Zimmerman Ben G.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00186.x
Subject(s) - saralasin , renal blood flow , plasma renin activity , endocrinology , medicine , renin–angiotensin system , angiotensin ii , radioimmunoassay , saline , kidney , renal artery , chemistry , blood pressure
SUMMARY 1. The objective of this study was to examine in anaesthetized dogs the graded effect of saralasin on renal prostaglandin E (PGE) release and to attempt to associate this change with its effects on plasma renin activity and renal blood flow. 2. Blood pressure and renal blood flow were monitored. Renal PGE concentration and plasma renin activity were measured by radioimmunoassay. Saralasin or saline vehicle was infused into the renal artery for 20 min. 3. Infusion of saralasin at the lowest dose of 0.25 m̈g/kg per min or saline vehicle did not alter either renal blood flow or plasma renin activity. Saralasin increased renal blood flow and caused a complete blockade of the renal vasoconstrictor response to exogenous angiotensin II at the two higher doses used (0.5 and 1 m̈g/kg per, min). Only the highest dose of saralasin increased plasma renin activity significantly. 4. Renal venous PGE concentration at the 5, 10 and 20 min periods of infusion was not changed significantly by any of these three doses of saralasin. We conclude therefore that the increases in renal blood flow and plasma renin activity caused by saralasin in the anaesthetized dog occur by mechanisms independent of changes in renal PGE.