Premium
EFFECTS OF A NON‐VASOCONSTRICTOR DOSE OF PHENYLEPHRINE ON PROSTAGLANDIN E 2 AND RENIN RELEASE IN ANAESTHETIZED DOGS
Author(s) -
Hisa H.,
Satoh S.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00184.x
Subject(s) - phenylephrine , plasma renin activity , blood pressure , renal blood flow , renin–angiotensin system , medicine , radioimmunoassay , prostaglandin , renal artery , endocrinology , kidney
SUMMARY Phenylephrine (1 μg/min) was infused into the renal artery of pentobarbitone anaesthetized dogs. Systemic blood pressure and renal blood flow were monitored. Arterial and renal venous blood samples were collected before and 10 min after the start of the infusion. Plasma prostaglandin E 2 concentration and plasma renin activity were measured by radioimmunoassay. This dose of phenylephrine did not affect systemic blood pressure and renal blood flow. However, both prostaglandin E 2 and renin secretion rates were increased by the infusion of phenylephrine. These results suggest that renal α‐adrenoceptors participate in prostaglandin and renin release independent of the changes in systemic blood pressure and renal blood flow.