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DEPENDENCE OF β‐ADRENERGIC RESPONSIVENESS ON THYROID STATE OF MALE RATS
Author(s) -
Threatte R. M.,
Barney C. C.,
Baker S. P.,
Fregly M. J.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00176.x
Subject(s) - chronotropic , medicine , endocrinology , triiodothyronine , isoprenaline , heart rate , body weight , basal (medicine) , adrenergic , basal metabolic rate , microgram , thyroid , chemistry , blood pressure , stimulation , receptor , in vitro , biochemistry , insulin
SUMMARY 1 The dose of thyroxine (0‐150 μg/kg body weight) administered subcutaneously daily to surgically thyroidectomized male rats was correlated significantly with their metabolic activity as assessed by rate of oxygen consumption and colonic temperature. 2 There was a significant dose‐dependent increase in total serum thyroxine, triiodothyronine and reverse‐triiodothyronine concentrations with increasing doses of thyroxine administered. 3 The cardiostimulatory response to administration of isoprenaline (8 μg/kg body weight s.c.) was also correlated directly with the dose of thyroxine administered. 4 The concentration of cardiac β‐adrenoceptors in these animals was correlated significantly with total serum thyroxine and triiodothyronine concentrations, basal heart rate, and the chronotropic response to administration of isoprenaline.