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THE EFFECT OF LONG TERM TREATMENT WITH A β‐ADRENOCEPTOR BLOCKER, l‐PROPRANOLOL, ON THE DISTRIBUTION OF CARDIAC OUTPUT OF THE LATE GESTATIONAL GUINEA‐PIG
Author(s) -
Bjellin Leif,
Mårtensson Lena
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00173.x
Subject(s) - propranolol , guinea pig , term (time) , medicine , distribution (mathematics) , cardiology , anesthesia , mathematics , mathematical analysis , physics , quantum mechanics
SUMMARY The effects of daily administration of propranolol on the distribution of cardiac output were studied in the late pregnant guinea‐pig. The animals were given either saline, 5 or 50 mg/kg per day of l ‐propranolol for 15 days during the last trimester of gestation. Blood flow responses were assessed by injecting 15 μm microspheres into the conscious animal one to two days prior to parturition. The fraction of cardiac output reaching the placentas was significantly reduced in both groups ( P <0.5 and P < 0.001, respectively), while flow to all other organs studied remained unaltered. It is suggested that propranolol exerts a selective effect on the placental vascular bed in the guinea‐pig.