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β‐ADRENOCEPTORS IN THE HYPERTROPHIED RIGHT VENTRICLE OF THE DOG WITH PULMONARY STENOSIS
Author(s) -
Sturm M.,
Taylor R. R.
Publication year - 1983
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1983.tb00167.x
Subject(s) - ventricle , medicine , muscle hypertrophy , right ventricular hypertrophy , cardiology , pulmonary artery , dihydroalprenolol , endocrinology , receptor , antagonist , partial agonist
SUMMARY 1.Right ventricular hypertrophy was produced in dogs by banding of the pulmonary artery for 28 days ( n = 7) and results were compared with those in sham‐operated dogs ( n = 5). 2. Myocardial noradrenaline and adrenaline levels were depressed in both the hypertrophied right ventricle and the non‐hypertrophied left ventricle and plasma levels were increased compared to the control dogs. 3. Myocardial β‐adrenoceptors were assessed in membrane preparations of both ventricles by 3 H‐dihydroalprenolol binding. No change in binding site concentration (pmol/mg membrane protein) or in binding affinity was found in either the hypertrophied right ventricle or in the left ventricle. 4. Divergent results of studies on β‐adrenoceptors in ventricular hypertrophy are difficult to reconcile.