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EFFECT OF ACUTE AND SUBACUTE TREATMENT OF CLONIDINE ON BLOOD pH, Pco 2 AND Po 2 IN MICE
Author(s) -
Gan E. K.,
Sattar M. Z. Abdul
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00840.x
Subject(s) - clonidine , chemistry , anesthesia , medicine
SUMMARY Measurements were made on blood pH, . P co 2 and Po 2 in mice after a single injection and following five weeks continuous clonidine hydrochloride treatment. A single injection of clonidine hydrochloride exerts no effect on blood pH, P co 2 and Po 2 but five weeks of continuous clonidine hydrochloride treatment lowers the blood pH and Pco 2 and raises blood Po 2 , suggesting acidosis has taken place. The acidosis may be attributed to rebound hypertension as a result of withdrawal of clonidine treatment.