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FURTHER STUDIES ON THE EFFECT OF ADENOSINE CYCLIC MONOPHOSPHATE DERIVATIVES ON CELL PROLIFERATION IN THE JEJUNAL CRYPTS OF RAT
Author(s) -
Tutton P. J. M.,
Barkla D. H.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00839.x
Subject(s) - adenosine , cell growth , cyclic adenosine monophosphate , endocrinology , chemistry , medicine , microbiology and biotechnology , cell , adenosine monophosphate , biology , biochemistry , receptor
SUMMARY 1. Cell proliferation in the jejunal crypt epithelium of rat was measured using a stathmokinetic technique. 2. Sodium butyrate was found to promote jejunal crypt cell proliferation. 3. N 6 , 0 2 '‐Dibutyryl cyclic adenosine monophosphate (cAMP), N 6 ‐monobutyryl‐cAMP and N 6 ‐monobutyryl‐8‐bromo‐cAMP were found to inhibit cell proliferation when compared to sodium butyrate treated tissues. 4. 8‐Chlorophenylthio‐cAMP was found to inhibit cell division when compared to untreated animals. 5. O 2 '‐Monobutyryl cAMP and 8‐bromo‐cAMP were not found to inhibit cell proliferation.