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COMPARISON OF THE EFFECTS OF ENDRALLAZINE, HYDRALLAZINE AND VERAPAMIL ON HUMAN ISOLATED ARTERIES AND VEINS
Author(s) -
Lipe Suzanne,
Moulds Robert F. W.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00832.x
Subject(s) - verapamil , serotonin , chemistry , vascular smooth muscle , medicine , antagonist , endocrinology , calcium , blood vessel , pharmacology , smooth muscle , receptor , biochemistry
SUMMARY 1. The antagonist effects of endrallazine (BQ 22‐708), hydralazine and verapamil have been studied on the contractile responses produced by various agonists on human digital arteries and metacarpal veins obtained post mortem. 2. Endrallazine and hydralazine antagonized the contractile responses to noradrenaline and serotonin in arteries by shifting the concentration‐effect curves to the right and by reducing the maximum responses to both agonists. Neither drug had any effect on responses to BaCU in either tissue. 3. The same concentrations of endrallazine and hydralazine which antagonized responses to noradrenaline and serotonin in arteries, had no effect on concentration‐effect curves to those agonists in veins. 4. Hydralazine was significantly more potent than endrallazine in reducing the maximum response to noradrenaline in arteries, and was less potent than endrallazine in reducing the maximum response to serotonin. 5. Verapamil antagonized the vasoconstrictor effect of all agonists tested in both arteries and veins. 6. It is concluded that in a similar manner to hydralazine, endrallazine has a direct effect on human vascular smooth muscle at concentrations which are probably similar to those occurring in vivo. Both hydralazine and endrallazine may produce selective arterio‐dilatation by preventing the release of bound calcium from intracellular storage sites, an effect which is different to that of verapamil.