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EFFECT OF RESERPINE ON RELAXANT RESPONSES OF CANINE FEMORAL ARTERIAL STRIPS
Author(s) -
Cauvin C. A.,
Devia C. J.,
Kirkendol P. L.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00826.x
Subject(s) - reserpine , hydralazine , chemistry , adenosine , pharmacology , medicine , muscle relaxant , endocrinology , anesthesia , blood pressure
SUMMARY 1 We studied relaxant responses to adenosine, glyceryl trinitrate, and hydralazine in control (n = 5) and reserpine pretreated (1 mg/kg i.m., 24 h prior; n = 5) canine femoral arterial strips contracted with noradrenaline. 2 Reserpine did not alter contractile responses to noradrenaline. 3 Reserpine pretreated tissues were supersensitive to glyceryl trinitrate, but not to adenosine or hydralazine.