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INFREQUENT RESPONSE BY DIABETIC RATS TO INSULIN‐LIPOSOMES
Author(s) -
Shenfield Gillian M.,
Hill J. C.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00819.x
Subject(s) - liposome , insulin , medicine , diabetes mellitus , endocrinology , sonication , pharmacology , chemistry , biochemistry , radiology
SUMMARY 1 Insulin‐liposomes of four different lipid combinations were given intragas‐trically to normal rats on twenty occasions and to diabetic rats on 164 occasions. 2 Normal rats showed no hypoglycaemic response to either sonicated or unsonicated liposomes. 3 Diabetic rats failed to respond to sonicated liposomes but six animals became hypoglycaemic on two occasions each after administration of unsonicated insulin‐liposomes. 4 The responsive animals had all been diabetic for more than 18 days but another thirty‐seven similar animals were unresponsive.