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NEOMYCIN AND EXPERIMENTAL HYPERTENSION
Author(s) -
Ingram Bruce W.,
Funder John W.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00816.x
Subject(s) - neomycin , medicine , endocrinology , blood pressure , mineralocorticoid , corticosterone , oral administration , kidney , glucocorticoid , pharmacology , renovascular hypertension , aldosterone , chemistry , biochemistry , hormone , antibiotics
SUMMARY 1. Acute glucocorticoid (corticosterone) hypertension in the rat is significantly attenuated by neomycin administration, presumably via altering gut bacterial steroid metabolism (Honour, 1981). 2. The effect on blood pressure of oral neomycin administration was therefore examined in two other models of experimental hypertension. 3. Neomycin significantly attenuates the development of one‐kidney, one‐clip hypertension but has no effect on the development of chronic mineralocorticoid (DOC‐salt) hypertension in rats. 4. The effect of neomycin on renovascular hypertension warrants further study to determine the mechanisms involved.

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