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PROSTAGLANDINS DO NOT MEDIATE RENIN RELEASE DURING SEVERE REDUCTION OF RENAL BLOOD FLOW IN CONSCIOUS DOGS
Author(s) -
Anderson W. P.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00804.x
Subject(s) - renal blood flow , plasma renin activity , renin–angiotensin system , blood pressure , blood flow , aspirin , endocrinology , fissipedia , medicine , kidney , carnivora , chemistry , anesthesia
SUMMARY 1. Renal blood flow was reduced by about 80% for 90 min in chronically instrumented conscious dogs following aspirin, indomethacin or no pretreatment. 2. There were no significant differences between the rises in plasma renin activity in the three groups of dogs (+ 7.9, s.e.m. = 1.4; +8.1, s.e.m. = 1.5; and +7.5, s.e.m. = 1.8 ng/ml per h, respectively) or in mean arterial pressure (36.0, s.e.m. = 5.6; 38.6, s.e.m. =2.6, or 35.4, s.e.m. =4.7 mmHg; respectively). 3. These results strongly suggest that prostaglandins do not mediate renin release during severe reduction of renal blood flow in conscious dogs.