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METABOLISM OF ARACHIDONIC ACID IN THE AORTA OF SPONTANEOUSLY HYPERTENSIVE RATS
Author(s) -
Dickens P.,
Dusting G.J.,
Doyle A.E.,
Martin T.J.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00803.x
Subject(s) - prostacyclin , arachidonic acid , endocrinology , medicine , thromboxane , prostaglandin , chemistry , aorta , metabolism , incubation , blood pressure , thromboxane b2 , cyclooxygenase , enzyme , biochemistry , biology , platelet
SUMMARY The metabolism of [ 14 C]‐arachidonic acid has been studied in isolated aortae from age‐matched spontaneously hypertensive (SH) rats and their normotensive Wistar Kyoto (WK) controls. High pressure liquid chromatography of extracts of the incubation mixture from both SH and WK rats revealed the presence of 6‐oxo‐prostaglandin F 1α , the hydration product of prostacyclin, and a single, broad peak of unknown metabolites. No thromboxane B 2 , or prostaglandins E 2 or F 2α could be detected in aortic incubations. The SH rats produced significantly more 6‐oxo‐prostaglandin F 1α than the WK rats, xbut there was no difference between the strains in the proportion of label appearing in the unknown peak of the chromatograms. These data confirm that vascular tissue of SH rats has enhanced ability to transform arachidonic acid into prostacyclin. Induction of these enzymes may be an adaptive response to elevated blood pressure, but the mechanism of this effect has yet to be elucidated.