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THE EFFECTS OF AN HISTAMINE H 2 ‐RECEPTOR AGONIST, IMPROMIDINE (SK & F 92676), ON THE GENERAL AND CARDIAC HAEMODYNAMICS OF THE INTACT DOG
Author(s) -
Maxwell G.M.,
Ness D.,
Rencis V.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00796.x
Subject(s) - coronary sinus , medicine , histamine , cimetidine , coronary vasodilator , vascular resistance , vasodilation , agonist , cardiology , hemodynamics , tachycardia , cardiac output , anesthesia , receptor
SUMMARY The effects of impromidine (16 nmol/kg intravenously) were studied in the general and coronary circulations of the intact anaesthetized dog. The drug caused tachycardia, increased cardiac output and coronary sinus flow, and induced minor changes in systemic and pulmonary arterial pressures. It increased left and right ventricular work, and decreased calculated resistance values in the greater and lesser circulations. Coronary vascular resistance fell, cardiac O 2 extraction increased. These changes were substantially prevented by treatment with cimetidine. The action of an H 2 ‐receptor agonist then is associated with a general and coronary vasodilator response, with maintenance of calculated cardiac efficiency.