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EFFECTS OF URETHANE‐CHLORALOSE ANAESTHESIA ON RESPIRATION IN THE RAT
Author(s) -
Hughes E.W.,
MartinBody R.L.,
Sarelius I.H.,
Sinclair J.D.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00788.x
Subject(s) - chloralose , respiration , anesthesia , tidal volume , pco2 , respiratory minute volume , respiratory system , medicine , ventilation (architecture) , respiratory rate , heart rate , blood pressure , anatomy , mechanical engineering , engineering
SUMMARY 1. Respiratory effects were measured in rats during six hours' anaesthesia with urethane and chloralose. 2. One‐hundred min from urethane administration, minute ventilation ( V E ) was minimal, arterial P O2 was low, arterial P CO2 was high; tidal volume ( V T ) and respiratory frequency ( f ) were relatively constant; hypercarbic and hypoxic responses were substantial. 3. Between 100 and 400 min from urethane administration, minute ventilation and frequency increased and became more variable, tidal volume remained relatively constant, arterial P O2 rose to 100 mmHg, P CO2 fell to 37 mmHg; hypercarbic sensitivity increased and hypoxic sensitivity decreased. 4. We conclude that the anaesthetic regime produced initial depression of respiration relative to metabolism but without great loss of respiratory chemosensitivity. The respiratory depression was prolonged by increased dosage with urethane and chloralose. 5. The variations between hypercarbic and hypoxic responses confirm that they operate through separate mechanisms.