Premium
LIPOSOME CARRIER VEHICLE FOR TRIIODOTHRYONINE
Author(s) -
Fountain M.W.,
Ganjam V.K.,
Schultz R.D.
Publication year - 1982
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1982.tb00784.x
Subject(s) - liposome , chemistry , vesicle , molar ratio , membrane , entrapment , saline , chromatography , molar , biophysics , biochemistry , surgery , biology , endocrinology , medicine , catalysis , paleontology
SUMMARY Liposomes (multilamellar vesicles, MLV) were prepared which entrapped triiodothryonine (T 3 ). The MLV were composed of dimyristoylphosphatidylcholine, cholestrol and dicetylphosphate as DMPC alone, DMPC:Chol (7:2 molar ratio) and DMPC:Chol:DCP (7:2:1 molar ratio). The optimal T 3 entrapment was within MLV composed of DMPC: Chol:DCP. The entrapped concentrations of T 3 was 63.1%. The MLV composed of DMPC:Chol:DCP did not leak T 3 from the MLV into buffered saline but did leak T 3 into serum (42.5% after 4 h). The MLV composed of DMPC:Chol:DCP exhibited a distribution of T 3 between membrane associated and membrane entrapped of 42:58%.