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EFFECTS OF GOLD SODIUM THIOMALATE ON CYTOSOLIC COPPER AND ZINC IN THE RAT KIDNEY AND LIVER TISSUES
Author(s) -
Sharma R. P.,
McQueen E. G.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00771.x
Subject(s) - gold sodium thiomalate , cytosol , chemistry , biochemistry , kidney , sodium , zinc , gold compounds , metabolism , copper , intracellular , endocrinology , medicine , biology , enzyme , rheumatoid arthritis , organic chemistry , combinatorial chemistry
SUMMARY 1. Male Wistar rats were given a single subcutaneous injection of gold sodium thiomalate and killed 7 days later. The binding of Au, Zn and Cu to the kidney and liver cytosolic proteins of control and gold‐treated rats was determined. 2. In the renal cytosol of Au(I)‐ exposed rats, the binding of Cu to the low‐molecular‐weight (LMW) proteins increased by 62%, and to the high‐molecular‐weight (HMW) proteins the binding decreased by 54%. The incorporation of Cu into the liver cytosolic proteins increased, in both, the HMW and the LMW proteins. The binding of Zn into the renal cytosolic proteins was increased by 39% (HMW proteins) and 100% (LMW proteins). Au(I) had little effect on the binding of Zn to the cytosolic proteins in the liver. 3. It is suggested that the therapeutic action of gold complexes may be mediated, to some extent, by its effects on the metabolism of Cu and/or Zn.