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OPIATES INHIBIT THE DOPAMINERGIC ENHANCEMENT OF THE RENAL RESPONSE TO ALDOSTERONE IN THE RAT
Author(s) -
Adam William R.,
Danks Janine A.,
Goland Gary
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00765.x
Subject(s) - aldosterone , dopaminergic , opiate , dopamine , endocrinology , (+) naloxone , medicine , chemistry , antagonist , agonist , mineralocorticoid , pharmacology , receptor
SUMMARY 1. Both naloxone, an opiate antagonist, and levorphanol, an opiate agonist, inhibit the enhanced renal response to aldosterone produced by both ℓ‐dopa pretreatment and a high K + diet. 2. This supports the evidence for a common mechanism of action for the enhancement of the renal response to aldosterone produced by ℓ‐dopa and a high K + diet. Whether this mechanism is dopaminergic or opiate is uncertain. 3. The inhibition of the enhanced response, produced by ℓ‐dopa, by opiates is consistent with previous findings of displacement of 3 H‐dopamine from renal homo‐genates by opiates and supports the hypothesis that the binding sites relate to the renal response to aldosterone.