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THE EFFECTS OF INDOMETHACIN IN TREATED HYPERTENSIVE PATIENTS
Author(s) -
Wing L. M. H.,
Bune A. J. C.,
Chalmers J. P.,
Graham J. R.,
West M. J.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00763.x
Subject(s) - blood pressure , medicine , supine position , plasma renin activity , crossover study , placebo , regimen , mean blood pressure , anesthesia , aldosterone , renin–angiotensin system , heart rate , alternative medicine , pathology
SUMMARY 1. Twelve treated hypertensive patients (ages 58–71 years) who had also been treated for joint disease participated in a randomized double‐blind crossover placebo‐controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6‐week period. 2. Blood pressure was increased in all patients throughout the indomethacin treatment period ( P <0.001) ‐ average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing). 3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use. 4. Plasma aldosterone concentration was reduced by 50% ( P <0.01), plasma renin activity was reduced by 43% ( P = 0.102) and plasma urea concentration was increased by 17% ( P <0.001) during indomethacin treatment. 5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens.