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REGULATION OF UTERINE SMOOTH MUSCLE BRADYKININ RECEPTORS BY BRADYKININ LEVELS AND ANGIOTENSIN CONVERTING ENZYME INHIBITOR IN THE RAT
Author(s) -
Yasujima M.,
Matthews P. G.,
Johnston C. I.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00759.x
Subject(s) - bradykinin , bradykinin receptor , captopril , medicine , endocrinology , receptor , angiotensin converting enzyme , chemistry , endogeny , ace inhibitor , blood pressure
SUMMARY 1. Bradykinin infusion (0.1 μg/min i.v.) decreased the number of uterine bradykinin receptors by 20% at Day 2. Bradykinin receptors returned to control levels at Day 7. 2. Captopril infusion (1.7μg/min i.v.) induced prolonged decreases in the number of uterine bradykinin receptors of 15% at Day 2 and of 13% at Day 7, respectively. 3. The number of uterine bradykinin receptors was increased in two‐kidney, one clip hypertensive rats by 19%. 4. These results suggest that endogenous bradykinin participates in the regulation of uterine bradykinin receptors. 5. Decreased uterine bradykinin receptors induced by captopril might reflect increased endogenous bradykinin.