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PSYCHOSOCIAL STRESS INDUCES TUBULOINTERSTITIAL NEPHRITIS UNRELATED TO HYPERTENSION IN CBA MICE
Author(s) -
Henry James P.,
Stephens Patricia M.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00754.x
Subject(s) - psychosocial , nephritis , endocrinology , clinical psychology , medicine , psychology , psychiatry
SUMMARY 1. Groups of mice interacting socially in complex population cages become hypertensive. Some also develop fatal chronic tubulointerstitial nephritis. 2. Long‐term administration of the cardioselective β‐blocker metoprolol controls stress‐induced elevation of plasma renin and adrenal tyrosine hydroxylase. It also normalizes blood pressure. Despite the effectiveness of this sympathetic blockade, the incidence of nephritis was not diminished. 3. The fact that stress‐induced increases of adrenal weight and plasma cortico‐sterone persist during metoprolol treatment points to the independence of the pituitary‐adrenal cortical system and its possible role in the aetiology of renal disease.