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EFFECT OF CONVERTING ENZYME INHIBITION WITH CAPTOPRIL ON IN VITRO ANGIOTENSIN PRODUCTION IN SHEEP
Author(s) -
Fei David T. W.,
Coghlan John P.,
Scoggins Bruce A.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00746.x
Subject(s) - captopril , angiotensin ii , in vitro , renin–angiotensin system , medicine , chemistry , angiotensin converting enzyme , endocrinology , blood pressure , biochemistry
SUMMARY 1. The effect of captopril on in vitro production of angiotensin I (ANG I), [Val5] ‐angiotensin II ([Vals]‐ANG II) and [Val4]‐angiotensin III ([Val5]‐ANG‐(2–8)) in central venous blood taken from sodium‐deficient sheep was studied. 2. Captopril enhances in vitro production of ANG I but blocks the in vitro production of [Val5] ‐ANG II and [Val5] ‐ANG‐(2–8). 3. The production of ANG I in blood is faster than that of [Val5]‐ANG II and [Val5] ‐ANG‐(2–8). 4. The half‐life of [Val5]‐ANG II and [Val5]‐ANG‐(2–8) in vitro in blood in the presence of captopril was 10 and 14 min, respectively. 5. This in vitro study suggests that the production of [Val5]‐ANG II and [Val5] ‐ANG‐(2–8) in blood forms a small part of the total body production of each peptide.