INCREASED CONVERSION OF ARACHIDONIC ACID TO VASODILATOR PROSTANOIDS IN SPONTANEOUSLY HYPERTENSIVE RATS | Zendy

Dusting G. J. | Zendy; Davies W. | Zendy; Drysdale T. | Zendy; Doyle A. E. | Zendy

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INCREASED CONVERSION OF ARACHIDONIC ACID TO VASODILATOR PROSTANOIDS IN SPONTANEOUSLY HYPERTENSIVE RATS

Author(s) -

Dusting G. J.,

Davies W.,

Drysdale T.,

Doyle A. E.

Publication year - 1981

Publication title -

clinical and experimental pharmacology and physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.752

H-Index - 103

eISSN - 1440-1681

pISSN - 0305-1870

DOI - 10.1111/j.1440-1681.1981.tb00744.x

Subject(s) - arachidonic acid , prostacyclin , vasodilation , endocrinology , medicine , chemistry , pharmacology , biochemistry , enzyme

SUMMARY 1. Vasodepressor responses to intravenous injection of prostacyclin, arachidonic acid, and nitroprusside were examined in anaesthetized, spontaneously hypertensive rats (SHR) of the Okamoto strain, and in their normotensive Wistar– Kyoto (WKY) controls. 2. Depressor responses to prostacyclin and nitroprusside did not differ significantly between the two strains. 3. The vasodepressor effects of arachidonic acid were greater and much more prolonged in SHR than in WKY. In rats treated with indomethacin (2 mg/kg) arachidonic acid induced only transient depressor responses which did not differ significantly between these strains. 4. It is concluded that SHR do not differ from WKY in their sensitivity to prostacyclin but they have enhanced ability to transform exogenous arachidonic acid into vasodilator prostanoids.

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