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SERUM CONCENTRATIONS OF DIGOXIN ENTRAPPED IN LIPOSOMES AFTER INTRAVENOUS ADMINISTRATION IN DOGS
Author(s) -
Fountain M. W.,
Pedersoli W. D.,
Ravis W. R.,
Ganjam V. K.
Publication year - 1981
Publication title -
clinical and experimental pharmacology and physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 103
eISSN - 1440-1681
pISSN - 0305-1870
DOI - 10.1111/j.1440-1681.1981.tb00162.x
Subject(s) - digoxin , serum concentration , liposome , medicine , pharmacology , oral administration , chemistry , endocrinology , anesthesia , heart failure , biochemistry
SUMMARY 1. Digoxin was associated into phosphotidylcholine liposomes at concentrations of 28–33 mol% in Hank's Buffer, pH 7.4 at 28°C. 2. Digoxin‐liposomes (digoxin concentration 0.022 mg/kg per dog per day) administered intravenously in five adult male dogs attained therapeutic serum concentrations (0.7–3.0 ng/ml) beginning with day 1 of administration. 3. Digoxin serum concentrations obtained by intravenous digoxin‐liposomes compared favorably with normal oral digoxin administration (0.022 mg/kg per dog per day) in all 5 dogs monitoring serum digoxin levels for 7 days showed no significant ( P <0.05) differences in mean serum digoxin concentrations ± s.e.m. on 6 of 7 days of treatments.